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KMID : 0371919890020010009
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Journal of Wonju College of Medicine
1989 Volume.2 No. 1 p.9 ~ p.15
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Comparisons of ATP Action on Portal Vein and Hepatic Vein in the Perfused Rat Liver
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Abstract
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While ATP is a potent vasodilator in many vascular beds, vasoconstriction occurs in other vasculatures. For instance, ATP increases vascular resistance in the isolated perfused rat liver. The present study was designed to investigate the site of ATP action in the hepatic circulatory system. Isolated rat liver perparation from Sprague Dawley was prepared by previous method. The liver on the liver platform was transferred to a strain-gauge weighing device and perfused with Krebs-Ringer bicarbonate solution at a constant pressure (25 CmH₂O). The liver perfusion was carried out in two ways: ⅰ) orthograde perfusion (perfusion through portal vein) ⅱ) retrograde perfusion (perfusion through hepatic vein). ATP was added into the perfusate reservior. Changes in liver weight by ATP addition were measured by a force transducer (Myograph F-60) and Physiograph (Narco).
The Key findings were:
1. ATP decreased the liver weight during orthograde perfusion
2. ATP increased the liver weight during retrograde perfusion
These results suggest that either 1) ATP increases resistance only in presinusoidal region or 2) ATP increases vascular resistance both in presinusoidal region and postsinusoidal region but the effect of ATP in the presinusoidal region exceeds that in the postsinusoidal.
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KEYWORD
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